SOLVED! See my followup post

I ran into a weird issue at work that ate up a few hours the other day. I was implementing a simple toggle button in React and if I clicked it say 10 times in 5 seconds, only ~9 of the times would register. I did a performance audit and it turned out that onclick was occasionally not firing, but onpointerup consistently worked.

So I bound the eventlistener to onpointerup, which solved the problem but... what could be the root issue? Any ideas?