Yes
Version 4.2 official web interface on Safari.
First I noticed the posts column flashing/jerking and redrawing when scrolling. Just awful.
Next I noticed I wasn't getting notifications, then realized I wasn't getting pushes for notifications at all—I have to reload the page to see favorites or mentions or the number flag.
I cannot edit the Advanced Interface columns at all: no "x" to close a column and the hamburger icon does nothing.